Dual action of ketamine confines addiction liability

  • Bellone, C., Loureiro, M. & Luscher, C. Drug-evoked synaptic plasticity of excitatory transmission in the ventral tegmental area. Cold Spring Harb. Perspect. Med. 11, a039701 (2021).

  • Di Chiara, G. et al. Dopamine and drug addiction: the nucleus accumbens shell connection. Neuropharmacology 47, 227–241 (2004).

    PubMed 
    Article 
    CAS 

    Google Scholar 

  • Lüscher, C., Robbins, T. W. & Everitt, B. J. The transition to compulsion in addiction. Nat. Rev. Neurosci. 21, 247–263 (2020).

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar 

  • Lüscher, C. & Ungless, M. A. The mechanistic classification of addictive drugs. PLoS Med. 3, e437 (2006).

    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Franks, N. P. & Lieb, W. R. Molecular and cellular mechanisms of general anaesthesia. Nature 367, 607–614 (1994).

    ADS 
    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Zanos, P. et al. Ketamine and ketamine metabolite pharmacology: insights into therapeutic mechanisms. Pharmacol. Rev. 70, 621–660 (2018).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Masuzawa, M. et al. Pentobarbital inhibits ketamine-induced dopamine release in the rat nucleus accumbens: a microdialysis study. Anesth. Analg. 96, 148–152 (2003).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Witkin, J. M. et al. The rapidly acting antidepressant ketamine and the mGlu2/3 receptor antagonist LY341495 rapidly engage dopaminergic mood circuits. J. Pharmacol. Exp. Ther. 358, 71–82 (2016).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Littlewood, C. L. et al. Mapping the central effects of ketamine in the rat using pharmacological MRI. Psychopharmacology 186, 64–81 (2006).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Rocha, B. A., Ward, A. S., Egilmez, Y., Lytle, D. A. & Emmett-Oglesby, M. W. Tolerance to the discriminative stimulus and reinforcing effects of ketamine. Behav. Pharmacol. 7, 160–168 (1996).

    CAS 
    PubMed 

    Google Scholar 

  • De Luca, M. T. & Badiani, A. Ketamine self-administration in the rat: evidence for a critical role of setting. Psychopharmacology 214, 549–556 (2011).

    PubMed 
    Article 
    CAS 

    Google Scholar 

  • Zanos, P. et al. A negative allosteric modulator for alpha5 subunit-containing GABA receptors exerts a rapid and persistent antidepressant-like action without the side effects of the NMDA receptor antagonist ketamine in mice. eNeuro 4, ENEURO.0285-16.2017 (2017).

  • Suzuki, T. et al. Effects of the non-competitive NMDA receptor antagonist ketamine on morphine-induced place preference in mice. Life Sci. 67, 383–389 (2000).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Luscher, C. & Malenka, R. C. Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. Neuron 69, 650–663 (2011).

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar 

  • Luscher, C. The emergence of a circuit model for addiction. Annu. Rev. Neurosci. 39, 257–276 (2016).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Ungless, M. A., Whistler, J. L., Malenka, R. C. & Bonci, A. Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature 411, 583–587 (2001).

    ADS 
    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Bellone, C. & Luscher, C. Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression. Nat. Neurosci. 9, 636–641 (2006).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Brown, M. T. et al. Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. PLoS One 5, e15870 (2010).

    ADS 
    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Conrad, K. L. et al. Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454, 118–121 (2008).

    ADS 
    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Kourrich, S., Rothwell, P. E., Klug, J. R. & Thomas, M. J. Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens. J. Neurosci. 27, 7921–7928 (2007).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Mameli, M. et al. Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nat. Neurosci. 12, 1036–1041 (2009).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Pascoli, V. et al. Stochastic synaptic plasticity underlying compulsion in a model of addiction. Nature 564, 366–371 (2018).

    ADS 
    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Brodie, M. S. & Dunwiddie, T. V. Cocaine effects in the ventral tegmental area: evidence for an indirect dopaminergic mechanism of action. Naunyn Schmiedebergs Arch. Pharmacol. 342, 660–665 (1990).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Hunker, A. C. et al. Conditional single vector CRISPR/SaCas9 viruses for efficient mutagenesis in the adult mouse nervous system. Cell Rep. 30, 4303–4316 (2020).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Corre, J. et al. Dopamine neurons projecting to medial shell of the nucleus accumbens drive heroin reinforcement. eLife 7, e39945 (2018).

  • Luscher, C. & Malenka, R. C. NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). Cold Spring Harb. Perspect. Biol. 4, a005710 (2012).

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar 

  • Zanos, P. et al. NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature 533, 481–486 (2016).

    ADS 
    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Ganguly, S., Panetta, J. C., Roberts, J. K. & Schuetz, E. G. Ketamine pharmacokinetics and pharmacodynamics are altered by P-glycoprotein and breast cancer resistance protein efflux transporters in mice. Drug Metab. Dispos. 46, 1014–1022 (2018).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Saland, S. K. & Kabbaj, M. Sex differences in the pharmacokinetics of low-dose ketamine in plasma and brain of male and female rats. J. Pharmacol. Exp. Ther. 367, 393–404 (2018).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Valjent, E. et al. Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. J. Neurosci. 20, 8701–8709 (2000).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Valjent, E. et al. Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proc. Natl Acad. Sci. USA 102, 491–496 (2005).

    ADS 
    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Bertran-Gonzalez, J. et al. Opposing patterns of signaling activation in dopamine D1 and D2 receptor-expressing striatal neurons in response to cocaine and haloperidol. J. Neurosci. 28, 5671–5685 (2008).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Pascoli, V. et al. Contrasting forms of cocaine-evoked plasticity control components of relapse. Nature 509, 459–464 (2014).

    ADS 
    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Pascoli, V., Turiault, M. & Luscher, C. Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour. Nature 481, 71–75 (2012).

    ADS 
    CAS 
    Article 

    Google Scholar 

  • Deroche-Gamonet, V., Belin, D. & Piazza, P. V. Evidence for addiction-like behavior in the rat. Science 305, 1014–1017 (2004).

    ADS 
    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Tan, K. R. et al. Neural bases for addictive properties of benzodiazepines. Nature 463, 769–774 (2010).

    ADS 
    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Cruz, H. G. et al. Bi-directional effects of GABAB receptor agonists on the mesolimbic dopamine system. Nat. Neurosci. 7, 153–159 (2004).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Melis, M. et al. Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area dopamine neurons through activation of CB1 receptors. J. Neurosci. 24, 53–62 (2004).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Paoletti, P., Bellone, C. & Zhou, Q. NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease. Nat. Rev. Neurosci. 14, 383–400 (2013).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Moghaddam, B., Adams, B., Verma, A. & Daly, D. Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J. Neurosci. 17, 2921–2927 (1997).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Ali, F. et al. Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines. Nat. Commun. 11, 72 (2020).

    ADS 
    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Kapur, S. & Seeman, P. NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D2 and serotonin 5-HT2 receptors—implications for models of schizophrenia. Mol. Psychiatry 7, 837–844 (2002).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Luscher, C. & Slesinger, P. A. Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. Nat. Rev. Neurosci. 11, 301–315 (2010).

    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar 

  • Can, A. et al. Effects of ketamine and ketamine metabolites on evoked striatal dopamine release, dopamine receptors, and monoamine transporters. J. Pharmacol. Exp. Ther. 359, 159–170 (2016).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Engblom, D. et al. Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron 59, 497–508 (2008).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Uchihashi, Y., Kuribara, H., Morita, T. & Fujita, T. The repeated administration of ketamine induces an enhancement of its stimulant action in mice. Jpn. J. Pharmacol. 61, 149–151 (1993).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Wiley, J. L., Evans, R. L., Grainger, D. B. & Nicholson, K. L. Age-dependent differences in sensitivity and sensitization to cannabinoids and ‘club drugs’ in male adolescent and adult rats. Addict. Biol. 13, 277–286 (2008).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Berman, R. M. et al. Antidepressant effects of ketamine in depressed patients. Biol. Psychiatry 47, 351–354 (2000).

    CAS 
    PubMed 
    Article 

    Google Scholar 

  • Bariselli, S. et al. Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction. Nat. Commun. 9, 3173 (2018).

    ADS 
    PubMed 
    PubMed Central 
    Article 
    CAS 

    Google Scholar 

  • Zweifel, L. S., Argilli, E., Bonci, A. & Palmiter, R. D. Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors. Neuron 59, 486–496 (2008).

    CAS 
    PubMed 
    PubMed Central 
    Article 

    Google Scholar 

  • Simmler, L. D. et al. Dual-action of ketamine confines addiction liability. Zenodo https://doi.org/10.5281/zenodo.5772449 (2022).

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