Nerve blocks may help counter the opioid crisis

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As I faced a prophylactic double mastectomy in hopes of averting cancer, I had many questions for my surgeons — one of which was about pain.

I was stunned when both my breast surgeon and plastic surgeon said that a nerve block would leave me pain-free for about three days, after which the worst of the pain would be over. Pectoralis nerve (PECS) blocks were developed to provide analgesia or pain relief for chest surgeries, including breast surgery.

I went through the mastectomy Dec. 1 after learning I had the PALB2 gene mutation that carried a sharply elevated risk of breast cancer as well as a higher risk of ovarian and pancreatic cancers. I also had my fallopian tubes and ovaries removed in July. I had learned about the gene mutation in April 2021, when one of my daughters found out she was a carrier.

As a 24-year breast cancer survivor and longtime health reporter, I was astonished that I had heard nothing about this mutation. I researched it and wrote “This Breast Cancer Gene Is Less Well Known, but Nearly as Dangerous” in August. After the double mastectomy, I also wrote about it for The Washington Post.

A dangerous breast cancer gene mutation changed my life. As a health reporter, I want you to know about it.

Just as my surgeons at NorthShore University HealthSystem predicted, I was released from the hospital the same day as my surgery and remarkably pain-free. I took one tramadol (a step down from stronger medications containing codeine) when I got home — only because it was suggested I take one pill. As I recovered, I only took Advil and Tylenol.

The opioid epidemic is a major public health issue in the United States and nerve blocks could be a solution. According to a study published in the Journal of Clinical Medicine in 2021, 1 in 20 surgical patients will continue to use opioids beyond 90 days. “There is no association with magnitude of surgery, major versus minor, and the strongest predictor of continued use is surgical exposure,” the study states.

The study describes regional anesthesia (nerve blocks) as having “excellent opioid-sparing properties” and accounting for same-day surgical discharge for a large number of painful orthopedic procedures that were previously performed on an inpatient basis.

According to a Clinical Journal of Pain article published in 2020, “Perioperative use of opioid-free anesthesia and analgesia regimens implemented as a significant component of ERAS (enhanced recovery after surgery) protocols have proved to reduce or replace opioid use.”

PECS blocks were created by Rafael Blanco at the King’s College Hospital in Dubai in 2011.

PECS blocks, used as part of the ERAS program, work to minimize pain, opioid use and nausea, and get mastectomy patients home sooner, and feeling much better than in years past, said Akhil Seth, director of Reconstructive Microsurgery at NorthShore University HealthSystem.

ERAS is a widely used program that focuses on the time before, during and after surgery and results in better outcomes in terms of length of stay in the hospital, pain control and opioid use, according to studies. ERAS was first introduced in the 1990s in Denmark by Henrik Kehlet who was frustrated that even surgeries performed laparoscopically kept patients in hospitals sometimes for six days.

NorthShore implemented ERAS for implant-based, post-mastectomy procedures using PECS blocks in 2018, said Rebecca Blumenthal, vice chair of Innovation, Department of Anesthesiology, Critical Care and Pain Medicine at NorthShore.

“The goal is patient comfort, with the fewest narcotics used,” Blumenthal said.

Nerve blocks are also used for other surgeries, such as colorectal, orthopedic, gynecologic and pancreatic ones.

Blumenthal said that because of ERAS, and the use of nerve blocks, there has been a reduction in the use of opiates of 75 percent for five surgical procedures at NorthShore clinics. She also said that many studies have shown a decrease in opioid use because of ERAS.

A 12-month review of ERAS, which included regional nerve blocks, at NorthShore clinics in 2018, and submitted to the Healthcare Leadership Council’s Opioid Compendium in the same year, showed a consistent reduction — 50 percent — in use of opioid medications in patients undergoing colorectal surgery during their hospital stay. An additional 10 percent who did use opioids used fewer that two doses. It also showed a 50 percent reduction in hospital median length of stay.

Surgeons were told to stop prescribing so many painkillers. The results were remarkable.

At NorthShore, patients are given a number of medications in the preoperative area. “They are analgesic, pain medications, but they are nonnarcotic,” Blumenthal said.

The medications I received are called multimodals. They included Tylenol, Celebrex and Gabapentin. I was also given Ketamine following a sedative verse.

Before surgery, the ERAS protocol includes a carbohydrate drink (having something in the stomach minimizes nausea), encourages nutrition and hydration, and uses multimodal medications to capture and control pain pathways, says an information sheet that doctors at NorthShore provide to patients before mastectomies. Patients also receive prophylactic anti-nausea medication. The reduction in pain meds also decreases nausea, itching, constipation and the inability to get up and move around.

Seth said patients are surprised to learn two surgeons will work on both sides at the same time — taking about four hours. Patients typically go home the same day.

“For the longest time, mastectomy was thought to be a daunting operation, requiring one to two nights’ stay,” Seth said. “The recovery is more streamlined than it used to be.”

My treatment included PECS I and PECS II blocks with a short-acting local anesthetic and a long-acting local anesthetic called Exparel. The nerve blocks are done with ultrasound guidance and provide pain relief for about three days.

“The combination of the PECS I and PECS II blocks provide pain relief for chest surgeries,” Blumenthal says. “The nerve supply to the breast and chest wall is extremely complex, and several nerves and nerve branches contribute to postoperative pain and need to be blocked to provide adequate pain relief.”

Study ties additional genes to increased breast cancer risk

Julie Gillette, 50, of Vernon Hills, Ill., underwent a prophylactic mastectomy in February. She decided to have the surgery upon learning she had the PALB2 mutation from her father’s side, and she had a mother with unknown origin metastatic lung cancer,diagnosed at 57. Gillette had the nerve blocks and said it made her first three days at home tolerable . “I couldn’t imagine going through this without” the nerve blocks, she said.

Megan Schwartz, 40, also a carrier of the PALB2 mutation, lives in southeast Central Texas and had a prophylactic double mastectomy in January at MD Anderson Cancer Center in Houston. She did not have a nerve block and managed pain for a few days with Tramadol every six hours alternating with acetaminophen. She did have mild discomfort but the Tramadol, she said, “really affected my ability to function well for the few days I took it. It made my brain feel foggy.”

Seth said that the technical aspects of a mastectomy has not changed much in the past 10 years, but the combination of ERAS and nerve blocks has made a difference.

“It is the enhanced recovery and nerve blocks that is the game changer,” he said. “It’s our ability to not only encourage patients to go through with it and feel comfortable — but our ability to offer reconstruction in an efficient and relatively easier way as opposed to 10-20 years ago.”

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